The line "One life, with each other, sisters, brothers" from the 1992 song "One" topped a poll conducted by music channel VH1.
Runner-up was the downbeat "So you go and you stand on your own, and you leave on your own, and you go home, and you cry, and you want to die" from The Smiths' "How Soon is Now."
A line from Nirvana's "Smells Like Teen Spirit" — "I feel stupid and contagious, here we are now, entertain us" — came third. Bob Marley's "Redemption Song" and Coldplay's "Yellow" took fourth and fifth places.
The top 10 was a mix of the affirmative and the acerbic, ranging from Robbie Williams' uplifting "Angels" — "And through it all she offers me protection, a lot of love and affection, whether I'm right or wrong" — to Radiohead's sour "Creep."
More than 13,000 people participated in the poll on the station's Web site, choosing from a list of 100 lyrics selected by music industry figures.